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Monitoring Public Water Supply for a Variety of Pathogens

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The simultaneous concentration and recovery of microbes in drinking water is important for responding to potential water-related events such as pathogen contamination or bioterrorism and could be a cost-effective technique for routine monitoring of drinking water quality. Scientists at the CDC have combined two techniques, ultrafiltration (UF) and insulator-based dielectrophoresis (iDEP) in series, to achieve significant concentration of microbes and pathogens for analysis.

Inventor First Name: 
Vincent
Blake
Yolanda
Eric
Inventor Last Name: 
Hill
Simmons
Fintschenko
Cummings
E Number Only: 
E-458-2013
Inv Is lead: 
Pat Filing Date: 
2010-10-07
2006-08-03
2005-08-03
Patent Authority: 
US
US
US
Patent Issue Date: 
2012-09-04
2010-10-12
Patent Number: 
8,257,568
7,811,439
Provider Technology ID: 
3309
Patent Application: 
12/899,671
11/499,371
60/705,933
LPM Zip: 
20892-9804
LPM Organization: 
NIH Office of Technology Transfer
LPM Phone: 
301-443-8518
LPM State: 
MD
Publication Caption: 
PMID 16269722
PMID 17483281
Publication Link: 
https://pubmed.ncbi.nlm.nih.gov/16269722/
https://pubmed.ncbi.nlm.nih.gov/17483281/
  • Device
  • Platform
  • Public Safety (NIOSH)
Updated On: 
Monday, March 9, 2020
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Related Patent Publish Date: 
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Publication Title: 

Hill VR, et al.

Hill VR, et al.

Related Invention: 
E-252-2013-0
E-273-2013-0
E-292-2013-0
Related Patent Application: 

60/641,303

PCT/US2006/000175

11/325,270

12/267,869

PCT/US2012/049784

14/419,641

60/989,768

PCT/US2008/084347

12/743,607

15/043,713

Related Patent Authority: 
US
PCT
US
US
PCT
US
US
PCT
US
US
LPM Last Name: 
Mitzelfelt
LPM FIrst Name: 
Jeremiah
Date Published: 
Monday, March 9, 2020
DTDT Classification: 
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Biodefense
Environmental Sampling, Testing
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Other (this will include others such as manufacturing, consumer products and vet
Device
Platform
Public Safety (NIOSH)
In vitro data available
Prototype
Infectious Diseases (parasitic)
DTDT Description: 
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Biodefense
Applications - Environmental Sampling/Testing
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Other (this will include others such as manufacturing, consumer products and vet
Device
Platform
Public Safety (NIOSH)
In vitro data available
Prototype
Infectious Diseases (parasitic)
Collaboration Sought: 
Yes
Collaboration Opportunity: 

The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a system to monitor water supplies for a variety of pathogens. For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.

Advantages: 
  • A rapid method for detecting the presence of a variety of microbes such as Cryptosporidium parvum oocysts and Enterococcus faecalis
  • Uses a combination of ultrafiltration and dielectrophoretic separation techniques versus available single method technology
  • Ability to separate live from non-viable microbes, thereby decreasing the chances of generating false-positive PCR results due to the presence of naked nucleic acid or non-viable microbes
  • Accurately assess low levels of pathogens in finished drinking water samples, whether due to natural or intentional contamination
Applications: 
  • Monitoring of municipal, commercial, public, and individual water supplies for drinking water quality
  • Monitoring source water, industrial effluent, hospital discharge, and military water infrastructures for pathogens
  • Assessing water in agricultural settings
  • Monitoring water quality in pools and other recreational settings
NIH Ref. No.: 
E-458-2013-0
IC: 
CDC
LPM Address: 
BG 5601FL RM 2G29 MSC 9804 5601 FISHERS LN
Inventor Lab URL: 
https://www.cdc.gov/media/spokesperson/
LPM City: 
Bethesda
Inventor IC: 
CDC
Sandia National Laboratories-California
Sandia National Laboratories-California
Sandia National Laboratories-California
Institute or Center: 
Lead Inventor: 

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